{"id":1929,"date":"2021-06-14T13:06:47","date_gmt":"2021-06-14T10:06:47","guid":{"rendered":"https:\/\/pdo.cumhuriyet.edu.tr\/?p=1929"},"modified":"2021-06-14T13:06:47","modified_gmt":"2021-06-14T10:06:47","slug":"prof-dr-celal-kaloglunun-projesine-tubitak-1002-hizli-destegi","status":"publish","type":"post","link":"https:\/\/pdo.cumhuriyet.edu.tr\/?p=1929","title":{"rendered":"Prof. Dr. Celal Kalo\u011flu&#8217;nun Projesine T\u00dcB\u0130TAK 1002 H\u0131zl\u0131 Deste\u011fi"},"content":{"rendered":"<div class=\"kvgmc6g5 cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">\u00dcniversitemiz T\u0131p Fak\u00fcltesi Histoloji-Embriyoloji Ana Bilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Prof. Dr. Celal Kalo\u011flu y\u00fcr\u00fct\u00fcc\u00fc olmak \u00fczere; Do\u00e7. Dr. Ertan Mahir KORKMAZ, Do\u00e7. Dr. Mahir BUDAK, Ar\u015f. G\u00f6r. Rasim HAMUTO\u011eLU ve Bursiyer Y\u00fcksek lisans \u00f6\u011frencisi Gizem AYDINAY ile birlikte y\u00fcr\u00fctece\u011fi &#8220;\u0130nfertil Erkeklerin Seminal Plazma S\u0131v\u0131s\u0131 ve Spermatozoas\u0131nda Sisteinden Zengin Salg\u0131 Proteini 2 (CRISP2) ve Semenogelin 1 (SEMG1) ile miR-582-5p, miR-27a, miR-21 ve miR-216b Ekspresyonunun Ara\u015ft\u0131r\u0131lmas\u0131&#8221; ba\u015fl\u0131kl\u0131 proje ile\u00a0T\u00dcB\u0130TAK ARDEB 1002 H\u0131zl\u0131 Destek Program\u0131 kapsam\u0131nda destek almaya hak kazanm\u0131\u015ft\u0131r.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fcn\u00fcn verilerine g\u00f6re \u00e7iftlerde %40-50 oran\u0131nda erkek kaynakl\u0131 infertilite ile kar\u015f\u0131la\u015f\u0131lmaktad\u0131r. Erkek infertilitesi, son zamanlardaki sperm parametrelerinde h\u0131zl\u0131 d\u00fc\u015f\u00fc\u015fle t\u00fcm d\u00fcnyada giderek artan sosyo-ekonomik bir problem haline gelmi\u015ftir. Bu durum \u00fcremeye yard\u0131mc\u0131 tedavi merkezlerinde giderilmeye \u00e7al\u0131\u015f\u0131lmakla birlikte, g\u00fcn\u00fcm\u00fczdeki tedavi yakla\u015f\u0131mlar\u0131 erkek infertilitesinin bilinmeyen y\u00f6nleri nedeniyle olduk\u00e7a s\u0131n\u0131rl\u0131 kalmaktad\u0131r. Bu nedenle erkek infertilitesine molek\u00fcler yakla\u015f\u0131mlar b\u00fcy\u00fck \u00f6nem arz etmektedir.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Bu projenin hedefi, yard\u0131mc\u0131 \u00fcreme teknikleriyle tedavi olmak isteyen erkek bireylerde temel sperm fonksiyon testlerine ilave olarak, CRISP2 ve SEMG1 proteinlerin analizi ve gen ekspresyonu ile MikroRNA\u2019lar (miR-582-5p, miR-27a, miR-21 ve miR-216b\u2019nin) aras\u0131ndaki etkile\u015fimin, insan spermatogenezi ve infertilitesini nas\u0131l etkiledi\u011fi sorusuna cevap bulmakt\u0131r.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Projeden elde edilecek veriler, erkek infertilitesinin bilinmeyen y\u00f6nlerine bir pencere a\u00e7\u0131lmas\u0131 ve bireye \u00f6zg\u00fc molek\u00fcler tedavi y\u00f6ntemlerinin geli\u015ftirilmesi a\u00e7\u0131s\u0131ndan kritik bir de\u011fer ta\u015f\u0131yacakt\u0131r. \u00d6zellikle, miR-21 ve miR-216b\u2019nin CRISP2 proteini, miR-582-5p, miR-27a, miR-21 ve miR-216b\u2019nin ise SEMG1 proteini \u00fczerindeki etkileri bu \u00e7al\u0131\u015fmayla ilk kez ara\u015ft\u0131r\u0131lacakt\u0131r. Dolay\u0131s\u0131yla \u00f6nerilen proje ile \u00fclke bilimine, \u00fcniversitemize ve t\u00fcp bebek merkezimizin tan\u0131n\u0131rl\u0131\u011f\u0131na katk\u0131 sa\u011flanacakt\u0131r.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Elde edilen sonu\u00e7lar \u0131\u015f\u0131\u011f\u0131nda, IVF kliniklerinde erkeklerden kaynaklanan infertilite oranlar\u0131n\u0131n azalt\u0131lmas\u0131 s\u00f6z konusu olup ba\u015far\u0131l\u0131 gebelik ve sa\u011fl\u0131kl\u0131 do\u011fum gebelik oranlar\u0131n\u0131n art\u0131r\u0131lmas\u0131 ile infertil \u00e7iftlerin toplumsal ya\u015fam kalitesi iyile\u015ftirilecektir.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Akademisyenlerimizi kutlar ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 dileriz.<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u00dcniversitemiz T\u0131p Fak\u00fcltesi Histoloji-Embriyoloji Ana Bilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Prof. Dr. Celal Kalo\u011flu y\u00fcr\u00fct\u00fcc\u00fc olmak \u00fczere; Do\u00e7. Dr. Ertan Mahir KORKMAZ, Do\u00e7. Dr. Mahir BUDAK, Ar\u015f. G\u00f6r. Rasim HAMUTO\u011eLU ve Bursiyer Y\u00fcksek lisans \u00f6\u011frencisi Gizem AYDINAY ile birlikte y\u00fcr\u00fctece\u011fi &#8220;\u0130nfertil Erkeklerin Seminal Plazma S\u0131v\u0131s\u0131 ve Spermatozoas\u0131nda Sisteinden Zengin Salg\u0131 Proteini 2 (CRISP2) ve Semenogelin 1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1930,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,1],"tags":[],"class_list":["post-1929","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-duyurular","category-habeler"],"_links":{"self":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts\/1929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1929"}],"version-history":[{"count":1,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts\/1929\/revisions"}],"predecessor-version":[{"id":1931,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts\/1929\/revisions\/1931"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/media\/1930"}],"wp:attachment":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}