{"id":1778,"date":"2021-02-26T20:54:16","date_gmt":"2021-02-26T18:54:16","guid":{"rendered":"https:\/\/pdo.cumhuriyet.edu.tr\/?p=1778"},"modified":"2021-03-01T12:40:20","modified_gmt":"2021-03-01T10:40:20","slug":"akademisyenimiz-doktora-sonrasi-bursla-strasbourg-universitesinde","status":"publish","type":"post","link":"https:\/\/pdo.cumhuriyet.edu.tr\/?p=1778","title":{"rendered":"Akademisyenimiz doktora sonras\u0131 bursla Strasbourg \u00dcniversitesi\u2019nde"},"content":{"rendered":"<div class=\"kvgmc6g5 cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">\u00dcniversitemiz Eczac\u0131l\u0131k Fak\u00fcltesi Farmas\u00f6tik Biyoteknoloji Anabilim Dal\u0131 Ara\u015ft\u0131rma G\u00f6revlisi Dr. Gizem \u00c7al\u0131\u015fkan, Fransa\u2019daki Strasbourg \u00dcniversitesi Molek\u00fcler Biyoloji, Genetik ve H\u00fccresel Biyoloji (IGBMC) Enstit\u00fcs\u00fc\u2019nde Laszlo Tora\u2019n\u0131n grubunda (<a class=\"oajrlxb2 g5ia77u1 qu0x051f esr5mh6w e9989ue4 r7d6kgcz rq0escxv nhd2j8a9 nc684nl6 p7hjln8o kvgmc6g5 cxmmr5t8 oygrvhab hcukyx3x jb3vyjys rz4wbd8a qt6c0cv9 a8nywdso i1ao9s8h esuyzwwr f1sip0of lzcic4wl py34i1dx gpro0wi8\" tabindex=\"0\" role=\"link\" href=\"https:\/\/l.facebook.com\/l.php?u=http%3A%2F%2Fwww.igbmc.fr%2Ftora%2F%3Ffbclid%3DIwAR2SR-_gn1x75FhOYzGaOa-LU09y4AY-EbBQGwfdAkd6rLQwRfRlKtKD0gA&amp;h=AT2hBZcZZV4lCDtOUD-oWnKH0GTY0y16WeHfiwGd8jaL-ZDzNbk9WC_BC-cZfrry7Ke6da460JnoV1Zgo58b_4ZI47Bato7NhsUuHxw-MiK2-7sE5deXB_ystHw60ej7RbSm&amp;__tn__=-UK-R&amp;c[0]=AT3JcO23fdUkyhfk-3QIlSe1L_HweW-lenL5QopQb2ycMdiSHIw4_Blx39UWqh7oKIscd0bW-nT5YGgJIXRm6HauzVHAAzyQ9rqqTRjdeaDnY7Pk1l1alY3EvSWrCzTDAj7SMsWWIU7YuJdiBhv6DKeXCkOPSQE2wxELiDdPq9uyOj-SyzeosBleMxbv1_pikQmZnUt_\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.igbmc.fr\/tora\/<\/a>), Ohio State \u00dcniversitesi\u2019nde (ABD) Poirier Laboratuvar\u0131 ile ortak y\u00fcr\u00fctt\u00fckleri Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc (NIH) destekli projede (Understanding how two related mammalian histone acetyl transferase co-activators, saga and atac, differentially regulate chromatin dynamics and transcription \/ NIH RO1 grant (USA) 1R01GN131626-01)&#8221; doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 olarak \u00e7al\u0131\u015fmalar\u0131na devam etmektedir.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Grubun ana ara\u015ft\u0131rma ilgi alan\u0131, b\u00fcy\u00fcme, farkl\u0131la\u015fma ve geli\u015fme s\u0131ras\u0131nda belirli bir h\u00fccrenin \u00e7ekirde\u011finde belirli protein kodlayan genlerin nas\u0131l a\u00e7\u0131l\u0131p kapat\u0131ld\u0131\u011f\u0131n\u0131 kontrol eden molek\u00fcler mekanizmalar\u0131n do\u011fas\u0131n\u0131n incelenmesidir. S\u00f6z konusu s\u00fcre\u00e7lerin d\u00fczg\u00fcn i\u015flememesi insanlarda \u00e7e\u015fitli hastal\u0131k durumlar\u0131na yol a\u00e7maktad\u0131r.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Grup ge\u00e7ti\u011fimiz y\u0131llar i\u00e7inde \u00e7ok say\u0131da metazoan n\u00fckleer transkripsiyon fakt\u00f6r\u00fcn\u00fc tan\u0131mlay\u0131p karakterize etmi\u015ftir. Bu d\u00fczenleyici proteinler aras\u0131nda, transkripsiyon ba\u015flang\u0131c\u0131na arac\u0131l\u0131k etmek ve \/ veya genomun epigenetik manzaras\u0131n\u0131 modifiye etmek i\u00e7in promoter DNA&#8217;da b\u00fcy\u00fck \u00e7oklu alt birim kompleksleri olu\u015fturan RNA polimeraz II ba\u015flatma fakt\u00f6rleri ve ko-aktivat\u00f6rleri bulunur. Tora laboratuvar\u0131 ger\u00e7ekle\u015ftirdi\u011fi \u00e7al\u0131\u015fmalar ile, b\u00fcy\u00fck ko-aktivat\u00f6r komplekslerinin (TFIID, SAGA, ATAC) genel ve h\u00fccre tipine \u00f6zel transkripsiyonun yan\u0131 s\u0131ra kromatin d\u00fczenleyici s\u00fcre\u00e7lere arac\u0131l\u0131k etmede kritik bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Farkl\u0131 \u00f6karyotik organizmalarda (maya, fare ve insan) gen ekspresyonu, genom stabilitesi ve kromatin mimarisinin kontrol\u00fcn\u00fc incelemek i\u00e7in biyokimyasal, genetik, h\u00fccre biyolojisi, g\u00f6r\u00fcnt\u00fcleme ve yap\u0131sal yakla\u015f\u0131mlar kullanarak h\u00fccresel sistemlerdeki d\u00fczenleyici s\u00fcre\u00e7leri daha iyi anlamay\u0131 ama\u00e7lamaktad\u0131r.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Daha \u00f6nce de T\u00fcbitak 2214-A bursu kapsam\u0131nda doktora tez \u00e7al\u0131\u015fmalar\u0131n\u0131 ger\u00e7ekle\u015ftirmek i\u00e7in IGBMC\u2019de Dr. Laszlo Tora\u2019n\u0131n grubunda bir y\u0131l s\u00fcreli bulunan Ara\u015ft\u0131rma G\u00f6revlimiz Dr. Gizem \u00c7al\u0131\u015fkan, IGBMC\u2019deki Dr. Frederic Coin\u2019n\u0131n grubu ile bilimsel i\u015fbirlikleri \u00e7er\u00e7evesinde histon asetilasyonu ve DNA tamir kompleksleri ile ilgili Nature Communications ve Nature Chemical Biology dergilerinde yay\u0131nlanan iki \u00e7al\u0131\u015fmada da yer alm\u0131\u015ft\u0131r.<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\">Gen\u00e7 akademisyenimizi kutlar ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 dileriz.<\/div>\n<div dir=\"auto\"><a class=\"oajrlxb2 g5ia77u1 qu0x051f esr5mh6w e9989ue4 r7d6kgcz rq0escxv nhd2j8a9 nc684nl6 p7hjln8o kvgmc6g5 cxmmr5t8 oygrvhab hcukyx3x jb3vyjys rz4wbd8a qt6c0cv9 a8nywdso i1ao9s8h esuyzwwr f1sip0of lzcic4wl py34i1dx gpro0wi8\" tabindex=\"0\" role=\"link\" href=\"https:\/\/www.nature.com\/articles\/s41467-019-09270-2?fbclid=IwAR3jrKA8icbPrHWohC9HTThFdXkYOoCg5QdqOK1Si1qLcST4dxMeHNIgaLc\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nature.com\/articles\/s41467-019-09270-2<\/a><\/div>\n<div dir=\"auto\"><a class=\"oajrlxb2 g5ia77u1 qu0x051f esr5mh6w e9989ue4 r7d6kgcz rq0escxv nhd2j8a9 nc684nl6 p7hjln8o kvgmc6g5 cxmmr5t8 oygrvhab hcukyx3x jb3vyjys rz4wbd8a qt6c0cv9 a8nywdso i1ao9s8h esuyzwwr f1sip0of lzcic4wl py34i1dx gpro0wi8\" tabindex=\"0\" role=\"link\" href=\"https:\/\/www.nature.com\/articles\/s41589-019-0354-y?fbclid=IwAR10o1dFtEGMh951fN2334cvMIxwX8RZ5qnuOYd_g7lkfPUZ7suG2dnWMkQ\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nature.com\/articles\/s41589-019-0354-y<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"o9v6fnle cxmmr5t8 oygrvhab hcukyx3x c1et5uql ii04i59q\">\n<div dir=\"auto\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1780\" src=\"https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1.png\" alt=\"\" width=\"862\" height=\"1080\" srcset=\"https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1.png 862w, https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1-239x300.png 239w, https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1-768x962.png 768w, https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1-817x1024.png 817w, https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1-88x110.png 88w, https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1-335x420.png 335w, https:\/\/pdo.cumhuriyet.edu.tr\/wp-content\/uploads\/str1-343x430.png 343w\" sizes=\"auto, (max-width: 862px) 100vw, 862px\" \/><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u00dcniversitemiz Eczac\u0131l\u0131k Fak\u00fcltesi Farmas\u00f6tik Biyoteknoloji Anabilim Dal\u0131 Ara\u015ft\u0131rma G\u00f6revlisi Dr. Gizem \u00c7al\u0131\u015fkan, Fransa\u2019daki Strasbourg \u00dcniversitesi Molek\u00fcler Biyoloji, Genetik ve H\u00fccresel Biyoloji (IGBMC) Enstit\u00fcs\u00fc\u2019nde Laszlo Tora\u2019n\u0131n grubunda (http:\/\/www.igbmc.fr\/tora\/), Ohio State \u00dcniversitesi\u2019nde (ABD) Poirier Laboratuvar\u0131 ile ortak y\u00fcr\u00fctt\u00fckleri Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc (NIH) destekli projede (Understanding how two related mammalian histone acetyl transferase co-activators, saga and atac, differentially [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1779,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,1],"tags":[],"class_list":["post-1778","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-duyurular","category-habeler"],"_links":{"self":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts\/1778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1778"}],"version-history":[{"count":2,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts\/1778\/revisions"}],"predecessor-version":[{"id":1787,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/posts\/1778\/revisions\/1787"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=\/wp\/v2\/media\/1779"}],"wp:attachment":[{"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdo.cumhuriyet.edu.tr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}